Diskobolos vs. Ramesses Ii

Diskobolos vs. Ramesses II There are many unique qualities in art that depict the different time periods. One can decipher specific eras based on the attributes of the painting or sculpture. Ancient Egypt sculptures are completely different from Ancient Greece sculptures by way of body position, facial expressions and materials used. Understanding backgrounds, time periods, and history of the sculptures are important when analyzing the works of art. Ramesses II is located at the University of Pennsylvania Museum of Archaeology. The statue was found at the Heracleopolis, Temple of Harsaphes, in Egypt â€Å"(Ramesses II). Archaeologists believe that the sculpture was made somewhere between 1897 and 1834 B. C during the time of the Middle Kingdom. The facial expression and body language illustrates his desire to be timeless. The sculpture is positioned in such a way that the body looks like it could stand the test of time. Made out of Quartzite stone, this sculpture is designed to pres erve the Pharaoh’s power and immortality. The Pharaoh is seated with both hands and feet placed purposely close to his body to signify success, reign and power. He sits upright in a tranquil manner reflecting power and kingship †(Ramesses II). Every inch of his body is made to perfection. His proportions are impeccable and is represents that of a god. The face of Ramesses is much, like all of the other Ancient Egyptian rulers during this tie period. The face has no personal qualities. â€Å"The same characteristics appear on almost all of his statues: a receding forehead with prominent brows; thoughtful, slightly downcast eyes; an aquiline nose with a broad bridge and rounded tip and a narrow mouth â€Å"(Ramasses II). The statue of Ramesses II is rather similar to the statue of Khafra. Ramesses II is seated in the exact same position as Khafra. Their hands and feet are close to the body while their faces have no personal attributes that give them their own identity. Both Statues were made to signify power and control. They wanted to be timeless and appear motionless. (See Figure 1) Figure 1. Statue of Ramesses II. The Ancient Greece era occurred after the Ancient Egyptian era and they had a very different design ascetic. In the classical period the Greeks created sculptures that were more life like. The sculptures actually looked like they were moving. Limbs were away from the body unlike that of Egyptian sculptures. The statues were asymmetrical and were positioned in a non-conventional way. A sculpture that has these characteristics is Diskobolos, It was originally created in bronze around 460-450 B. C. The statue is of a man about to throw a disk. He is bent at the waist with one arm out to the side. The potential energy expressed in this sculpture's tightly-wound pose, expressing the moment of stasis just before the release, is an example of the advancement of Classical sculpture from the Egyptian period†(Diskobolos). This position demonstrates harmony and balance because every inch of his body is working together to create a smooth movement and throw. Each movement is essential to establish the position. â€Å" The working left arm balances the engaged right leg in the forward position an d the relaxed right arm balances the free left leg†(Janson, 124). The facial features are much more realistic. In this sculpture his face looks like he is working hard and focusing on the game. Emotions were thought out at this time period when creating art. If someone was happy they looked like it and if some was in pain they had the look of extreme discomfort. Also the idea of movement is really predominant in this time period. All the statues look like they are going to take a step or throw something in order to create movement. (See figure 2) figure 2. Statue of Diskobolus Both Greek and Egypt Sculptures have considerable differences but they also have some similarities. Both cultures valued the idea of a perfect muscular body yet one valued movement over timelessness. Each culture is unique with the artwork and sculptures that they left behind for us to study. They each donated something special to us and each art style had a profound effect on how we look and judge art. Works Cited â€Å"Discobolus. † Sir Thomas Browne. Web. 17 Nov. 2009. . Janson, H. W. Janson's history of art the western tradition. Upper Saddle River, NJ: Pearson Education, 2007. Print. â€Å"Ramesses II. † Grove Art Onine. Oxford university press. Web. 10 Nov. 2009. .

Instructions for Blockbuster

Effective 2005, Blockbuster began a new policy of no late fees. In late 2005, Blockbuster was experiencing financial distress and needed emergency financing to stay afloat. The stock price dropped from $12 to $4, and the debt traded as junk.Question 1: Analyze the soundness of the decision, given the contribution that late fees made to prior years’ results. Does an analysis of the company’s cash flows support or refute the company’s decision?What you need to do is as follows: Get the data from 2002-2004, which should all be in the 2004 10-k, compute what free cash flow would have been without the late fees during 2002-2004, and project what 2005 free cash flow would be if the no late fee policy stays in place and business doesn’t improve. Late fees are referred to by the euphemism â€Å"extended viewing fees†.Question 2: Is there any evidence that the 2005 results benefited from the no-late fees policy? If so, quantify the specific amount you believ e that the basic business improved due to the no late fees.Compare your projected 2005 free cash flow to the actual (from the 2005 10-k). Consider the known reasons that 2005 results differed from the no-late expectation from question 1: i) there were some large fees actually collected, ii) interest costs were higher than expected, iii) Capex was way lower than any reasonable expectation, and iv) a lot of cash went into working paper to replace the trade credit that was withdrawn. Use these four ‘known unexpecteds’ to form an adjusted expectation for 2005, and then compare that number to the actual.Notes: 1. It is important to remember the effects of tax. In particular, free cash flow should change by the after-tax amount of late fees, not by the gross amount of late fees. 2. Late fees are referred to in the income statement by the euphemism â€Å"extended viewing fees†. 3. Focus on Blockbuster’s data and  don’t get distracted by an analysis of Ne tflix. Avoid making testimonials about how much better Netflix is than Blockbuster, or vice versa.

Authentication Mechanism for Fast Handover PMIPv6 Networks

Authentication Mechanism for Fast Handover PMIPv6 Networks N.S.Nandhinee S.Kayalvizhi    Abstract —The Internet Engineering Task Force (IETF) proposed a host-based mobility management protocol, called Mobile IPv6 (MIPv6) protocol for mobile nodes (MNs) to maintain continuous service when they move among different foreign networks. However, Mobile IPv6 does not provide good service for real-time applications because it causes longer disruptions when the handoff takes place. Recently, the IETF NETLMM working group developed a network-based localized mobility management protocol called Proxy Mobile IPv6 (PMIPv6) to reduce the handoff latency of MIPv6. PMIPv6 still suffers from packet loss problem and signaling overhead. This paper performs a Bicasting scheme to reduce packet loss, use the piggyback technique to reduce the signaling overhead, also provides Authentication mechanism for protecting valid user from attacks in PMIPv6 networks. Keywords—Authentication, bicasting, handover, piggyback, Proxy Mobile IPv6 (PMIPv6) 1 . Introduction As wireless technologies have grown, all the people want to use wireless networks while moving from one place to another. At the same time Mobile MIPv6 was developed by the internet Engineering Task Force (IETF) to support the Mobile Node. Even after introducing the Mobile IPv6 Mobile Nodes (MNs) did not receive any data packets when it performs the handover that involves , IP address configuration, movement detection and location update latencies. To reduce the handover latency, Fast Handover has been developed. Fast handover performs the movement detection and IP address whenever the Mobile Nodes move from one location to another. Therefore Fast handover protocol reduces the handover latency. However , MIPv6 cannot satisfy all the requirements of real time applications such as video streaming service and voice over internet protocol (VoIP) service due to its high handover latency. To address this problem, the Internet Engineering Task Force (IETF) NETLMM working gro up developed a network based localized mobility management protocol called Proxy Mobile IPv6 (PMIPv6) to reduce the handoff latency of MIPv6.Moreover, PMIPv6 provides the IP with the mobility to support MNs without requiring its participation in any mobility-related signaling. Although PMIPv6 reduces lots of handoff latency compared with MIPv6, it still suffers from packet loss, signaling overhead and inefficient authentication procedure problems during handoff. This is because PMIPv6 does not use any buffer mechanism during the handoff procedure and performs the authentication and registration phases separately. Therefore this paper used a bicasting scheme for packet loss and piggybacking technique for signaling overhead. 2. Related works 2.1. survey on fast handover Chaung and Lee [2] proposed handoff schemes for PMIPv6 networks perform the authentication and registration phases separately, resulting in longer handoff latency. A. Pre-Handoff procedure The movements of an MN is det ected using the MAG and it performs mobility-related signaling with the LMA in place of the MN. The pre-handoff phase starts only when the MN is going to leave the range of the serving MAG (i.e., MAG1). First, MAG1 sends a handoff initial (HI) message to the target MAG(i.e., MN-ID) and the address of the target MAG. Then , MAG2 sends back a handoff acknowledgement (HACK) message to MAG1, and then a bi-directional tunnel is built between MAG1 and MAG2. After the bi-directional tunnel is built , the buffer of MAG2 prepares to buffer.

Morality of Abortion Essay Example | Topics and Well Written Essays - 1250 words - 1

Morality of Abortion - Essay Example Therefore, the debate between the two groups continues endlessly. Since either party fails to shake off the context-specificity of abortion, the groups on either side of abortion makes them vulnerable to each other’s critiques (Marquis 183-187). Personhood, right to life, and ethics are several recurring keywords in both the pro and contra abortion debate. Often these themes serve as the grand principles of the attempts to validate the arguments of either party on the issue of abortion. But unfortunately, these themes themselves have been contaminated by the context-specificity. In his article, â€Å"A Defense of Abortion†, though Jarvis Thompson attempts to deal with the permissibility of general abortion, he mostly hovers around some specific contexts of abortion that may draw the readers’ emotional support, and then rational, to his stance on the issue of abortion. Indeed Thompson’s approach is to establish a person’s or a woman’s right to abortion from a pure ethical point of view. He argues that since an unexpected conception of a baby in its mother’s womb due to a rape or other cases is in direct conflict with its mother’s right to choose, the mother’s choice to abortion may proved to be mean and selfish according to the existing morals of a society, but she has the right to abort the baby. Thompson’s success lies in drawing a clear dichotomy between morals and ethics on the issue of the abortion. According to him, a mother’s right to choose to deprive her unborn baby from its right to life through abortion should be based on ethics, whereas her choice to allow the baby to live in her womb is a question of her and her society’s morality. Thompson’s propounded ethics asserts that if one’s right to choice does not come into direct conflict with another’s right to life, he or she cannot be held responsible for the violation of

Websites Comparison Coursework Example | Topics and Well Written Essays - 750 words

Websites Comparison - Coursework Example The two websites have the different secondary audience. The secondary audience for the WebMD is patients of sick people or people carrying out research on medical subjects. Students studying medicine can use the information for studies. The secondary audience for Nationals Institutes of Health is the learning institution, NGO’s and government agencies. In order to provide medical help to the community NGO’s can use the information to identify the health institution available. The government can also monitor the health program available in order to make an improvement. The two websites use connection strategies to deliver the information to the primary audience. WebMD uses a connection from Facebook, Twitter, and Pinterest. People can share the information on the website to those social media platform and increase audience. National Institutes of Health uses You Tube, Facebook, Twitter and email updates connections. The subscribers are updates through email on daily basi s. Some of the jargons in WebMD include prodigy, sclerosis facts, schizophrenia and rheumatoid arthritis. Those jargons are used to explain different body complication. National Institutes of Health web has more scientific jargons and experiments that are technical. The images in the website include images of practical being carried out in a scientific lab. An average sentence length in the WebMD website is ten words and a paragraph is seven to eight sentences. Each paragraph is composed of different information.

Operational Amplifiers Assignment Example | Topics and Well Written Essays - 2500 words

Operational Amplifiers - Assignment Example In case the device is to be used as a gain block, an amplifier that is ideal should have infinite gain. Similarly, the input impedance of the amplifier should also be infinite so as not to draw any power from the driving source. The most commonly used method for analysing stability of an amplifier is the Bode analysis. The basis of measurement here is creation of an open loop magnitude and phase plot to attain the stability for a closed loop. These are also indicators of gain and phase margin. Derivation of the phase margin is done by finding the intersection of the unity gain frequency response of closed loop curve to the open loop response curve (Schmid, 1995). At this frequency the phase will be read from the phase plot. Then the value gotten is subtracted from one hundred and eighty degrees to get the desired phase margin. Gain margin can also be determined in the magnitude plot by the frequency at 180 degrees. Operational amplifiers are linear devices possessing all the qualities that are required to have ideal amplification of direct current. Operational amplifiers are used for filtering or conditioning signal. They can also used to subtract, add, integrate and differentiate mathematical operations. An ideal amplifier consists of three terminals. The negative terminal is the inverting input while the positive terminal is the Non-inverting input. The last terminal is the output port of an operational amplifier. When the same circuit is considered in terms of impedance, R1 = Z1, R2 = Z2. Capacitors and inductors effectively change their impedance dependent upon frequency (ZC = 1/jωC). With capacitors in the circuit as in Figures 1 and 2, ÃŽ ² will be determined by frequency. The gain of the amplifier is constant as the frequency of the signal increases from 1 Hz to around 200Hz. As the frequency of the signal increases beyond the low break frequency i.e. 200Hz the gain increases until it reaches its

DB 7 Research Paper Example | Topics and Well Written Essays - 1000 words

DB 7 - Research Paper Example The cash inflow is good news to creditors whose interest is in availability of cash from which the organization can fulfill its debts. The cash inflow from operating activities, especially net profit, is also good news to the company’s stockholders who are interested in the interest that they can earn from their shares because such rates depend of profitability (Porter and Norton, 2012). The management, as the organization’s custodian, also delights in the positive cash flow as an indicator of their effectiveness and efficiency. The positive cash flow does not identify negative effects on the stakeholders (Harrison, Horngren, 2008; Porter and Norton, 2010). RadioShack’s main use of cash and implication on stakeholders The company’s main cash application is in financing activities through purchase of treasury stocks. This means that the corporation repurchased its stock and this has significant impacts on the management and stockholders. It offers benefits to stockholders because of the interest earned in selling their shares to the company. It however has the disadvantage of lost stake and shareholders’ reduced decision-making authority as the entity gains more decision-making authority. The purchase however increases the management’s autonomy and other benefits to the organization such as ensuring a favorable market value for its stock, expanding its returns on investment, and protecting the organization from potential takeover. The management also gains the power to purchase other companies (Needles and Powers, 2012). Question 2: Most significant differences between net cash provided by operations and net income The most significant differences between net cash from cash flow statement and net income from the income statement are identified in adjustments for reconciling net income to the net cash. The most significant difference is with respect to accounts payable, accrued expenses, income taxes payable and other pay ables, whose total value amount to $ 85 million. Another significant difference is realized through depreciation and amortization that account for a $ 84.2 million variation. Inventories and accounts and notes receivables are the other significant differences between the two cash values. Inventories accounted for a cash outflow of $ 60.4 million while accounts and notes receivables accounted for a reduction in net cash flow by $ 39.9 million (Stittle and Wearing, 2008). Question 3: Comparison of RadioShack’s sales and purchase of fixed assets in 2010 relative to previous years The net addition of fixed assets in the year 2010 is less that the net additions in the previous years. This means that the difference between purchase and sales during the accounting period was less than the difference in preceding periods. While there was a net increase in value of property, plant, and equipment by $ 80.1 million, the year ended 2009 realized a higher value increment of $ 80.8 million . The year ended 2008 realized higher net increment of $ 85.6 million, 5.5 million more than net fixed asset purchase for the year ended 2010. It is however important to note that the changes are not representative of pure purchase of sales of the fixed assets but a sum interaction of the two (Stittle and Wear

Gender isues in employment Essay Example | Topics and Well Written Essays - 2000 words

Gender isues in employment - Essay Example "It is a people business. Tourism is the largest employer of any industry in the world now; its growing by leaps and bounds. And tourism is the largest employer in San Francisco. This gives women a chance to hone their management skills." (Armstrong, 2006) Employment opportunities in the hospitality profession abound all over the world. In the majority of West European countries women predominate in the hotel staff but unfortunately, only a small number of women are in management positions. Purcell postulates that there are three mutually-reinforcing but distinct elements which influence the allocation or denial of particular work to women: labour cost, sexuality and patriarchal prescription (Purcell, 1996) A study by Kattara in 2005 on career challenges of female managers in Egyptian hotels found out that the majority of female managers were not in situations that would lead them to the positions of general managers. â€Å"The study detected several factors preventing female managers from reaching the glass ceiling. The stepwise multiple regression showed that 35.5 percent of the variance in the existence of challenges could be explained by four factors; gender discrimination, relationships at work, mentor support and lack of network access† (Kattara, 2005) In the hospitality sphere there also exists a strong gender-segregation in work. Burgess, in her research, claims that there exist considerable discrepancies between the career development and salaries of men and women in the hospitality industry. The most prestigious and, therefore, better-paid job positions are occupied by men (Burgess, 2003).. Female employees tend to work in housekeeping, the kitchen or in the food and beverage departments. While there tends to be an equal amount of men and women in front office, top managerial positions still tend to be held by men. There appears to be a constant conflict between mutually beneficial

Business Essay Example | Topics and Well Written Essays - 750 words - 15

Business - Essay Example We understand that these days multinational companies have a tendency to transfer their manufacturing facilities to third world countries, where working conditions do not always reflect the global principles of human rights. In order to fight the problem of discrimination all of the four businesses of our company - Veolia Water, Veolia Environmental Services, Veolia Energy and Veolia Transport – are promoting diversity at work, as well improving labor relations and fair compensation. A "Diversity Label" award of France we received in 2010 serves us as a signification of the fact that our efforts have brought the desired results. We are eagerly employing and developing careers of women, older people, people with disabilities and people of different ethnical backgrounds (An attractive social policy 2011). Unfortunately, the situation is not similar in all the companies. The famous Wal-Mart case firing a disabled man who had worked for the company for eight years is an example of totally irresponsible treatment of employees (Convey 2011). The company was sued and, as a result, customer loyalty got decreased, respect of stakeholders lost and social disapproval arose. As for promoting greater environmental responsibility, Veolia has developed and is implementing biodiversity and resource conservation and health and living environment protection programs. Veolia Water reduces the waste of water and develops the recycling technologies of water. Veolia Environmental Services focus on reducing the pollutant load of waste and protect environment. Veolia Energy focuses on pollution emission treatment, and Veolia Transport ensures the order of public transport (Business Activities 2011). However, we do understand that, though we take actions for protecting the environment, we should pay more attention to actual promotion of greater environmental responsibility. A good example of

Leadership management and change Essay Example | Topics and Well Written Essays - 3500 words

Leadership management and change - Essay Example So, the values of Tesco can be lined up as follows: Tesco has a consistent strategy that has allowed the company to strengthen their core business in UK and also helps to drive expansion towards new markets. The underlying principle for this strategy is to widen the scope of the business as the company is able to deliver sustainable growth for long term. This can be done by following the customer in domestic as well as in the new markets of abroad. They had taken a strategy to diversify the business in the year of 1997. The new businesses that have been started and developed due to this strategy over the last 13 years are now profitable and competitive enough. Even Tesco is now becoming a market leader in many of their markets outside UK. The group is able to make good progress. This strategy basically has five objectives. Since the 1990, the company has been seeking out for new opportunities for generating returns and growth for shareholders in new market. Today, the group is able to operate in 13 markets outside the United Kingdom and includes that of Asia, Europe and North America. The full appearance in international retailing is not something which can happen overnight. It needs long term approach. Tesco has evolved a strategy based on six factors. Those are as follows Flexibility: Every market is different from each other. So they have their unique approach. For example, in Japan fresh products are preferred and so they tend to shop several times a week and because of that reason, the stores are located in the heart of the community. So, it would be prudent to enter into that market through acquiring of discount supermarket operators. Maintain Focus: The group understands the customer’s requirement. They know that customers usually looking for great value and great choice. So, the company’s wish to prove themselves as the leading local group needs long term effort. Use multi-formats:

The eventual fall of the Ottoman Empire Essay Example for Free

The eventual fall of the Ottoman Empire Essay How far did the reforms during the period 1826-39 contribute to the eventual fall of the Ottoman Empire? The Ottoman Empire (1299-1924), founded as a medieval dynasty, collapsed and re-emerged as a modern constitutional state in less than seven centuries. The crucial question is why? What caused so momentous a transformation? There is much historical debate as to the causes for, and underlying factors in the empires collapse. Ive focused my study on the reforms passed during the period 1826-39, for I would consider these central in understanding the nature of the empires transformation. The years between 1826 and 1839 were a key turning point in the empires history and relations with foreign powers. In this period, crucial wars were fought, reforms ratified and institutions dismantled. Sultan Abdulmecid declared in 1839, [my empire] will prove [] that it is worthy of a prominent place in the concert of civilised nations. As Suraiya Farooqhi et al, in their detailed study of the latter centuries of the empires history put it, such events are important for they physically acknowledged, reaffirmed, and maintained the new centralizing/westernizing course of the Ottoman state.i Historians, whose studies are based foremost on European sources e.g. Lord Kinross and Feroz Ahmadii, tend to see the reforms as progressive, and attribute the empires collapse to a failure to industrialise. On the other hand, other historians, e.g. E.Eldemiii and Professor Maksudoglu, as well as Stanford J. Shawiv, all of whom rely more heavily on Ottoman sources, see the reforms as far more degenerate. Maksudoglu suggests Osmanli [Ottoman] sources have been neglected and ignored. v Shaw argues that Ottoman history has been discussed but always from the European perspective, through the light of European prejudice, and largely on the basis of European sources.vi It is due to a neglect of Ottoman sources that many historians have misinterpreted the causes of the empires collapse; there exists an unnatural bias towards the conventional European justification. As Goodwin suggests, foreign historians tend to blame the international forces of capitalism their capital, their force and suggest that the West reduced the empire to a peripheral producer of raw materials.vii Nevertheless, most historians agree that European influence proved to be of ever-increasing significance in determining the empires transformations. Ahmad suggests that ministers from the Sublime Porte visited Europe, in particular France, more frequently and returned home impressed with what they saw and learned.viii In the 1830s, an Ottoman poet wrote: Go to Paris, young sir, if you have any wish; if you have not been to Paris, you have not come into the world.ix Although the poet was probably writing for the purposes of entertainment, not necessarily for historical accuracy, the extract offers insight into not only the opinion of the poet, but his influence on the audiences perception. The likelihood of the sources reliability, although anonymous, is further strengthened when looked at in the context of Eastern, in particular Muslim, society. The oral tradition was, and still is of significant importance. The point made by Ahmad and the poet shows how the Ottoman view of Europe shifted significantly in the period; Europe had something to offer the empire. Ministers visiting Paris understood the basis of European superiority and in turn saw the need to drastically alter their own system. The Janissary purge of 1826 was first of the Sultans drastic alterations. It was impossible to introduce military and administrative reform whilst faced with the staunch opposition of the conservative ulema [Islamic religious authority], supported by the Janissaries. Ahmad agrees; as he puts it, such schemes were impossible to introduce while the conservatives were so strongly entrenched. Backed by the Janissaries, they were sufficiently powerful to depose reformist sultans and execute their grand viziers.x As Mansel points out, the official history of enumerated acts of insubordination by the corps [stretched] back to the reigns of Selim I and Suleyman.xi By combining evidence from these sources, we can see that the abolition of the corps, also known as the the purging of the garden of the empire of savage and useless weeds, or the Blessed Event was inevitable. The abolition removed the final vestiges of conservatism, thus making it possible for foreign governments to influence the Sultan and the Sublime Porte [Ottoman government]. It was the beginning of an era of almost continuous reform, as Mansel put it, it seemed that only the Janissaries had delayed the empires return to the openness of the reign of Fatih and the early sixteenth century.xii The Janissaries created a climate of fear and disorder. The ulema had largely supported the Janissary reign of misrule, preferring conservative anarchy to innovation and reform.xiii By 1826 the Janissaries had managed to alienate the ulema, and even the common citizens were against them. This was partly due to the treatment of the citizens by the Janissaries and also, as Ahmad suggests, because of the Janissarys poor performance in the Greek insurrection of 1821. Mahmud II waited eighteen years to abolish the Janissaries, who had overthrown and executed his predecessor, Selim III. They were becoming a law unto themselves and were now even unable to fight; they were less soldiers, and more private citizens who just so happened to be on the military payroll. My argument is strengthened by R. G. Grant, who agrees that the Janissaries, once so admired, became a weakness through their political intriguing and their conservatism, which obstructed military reform.xiv Although Grant is correct, the Janissaries did obstruct military reform, they helped to defend the empires citizens against the Sultans excesses, as Maksudoglu argues, [after 1826] top officials lived a luxurious and corrupt life, while the government borrowed substantial sums of money from European powers, and inflation reached unprecedented levels. xv As Goodwin suggests it was no longer the Ottoman peasant to whom the sultans had to answer for their extravagance. There were no Janissaries now to growl at the dissipation of the court.xvi In 1875, due to the Sultans lavish spending, the empire declared bankruptcy. There is no doubt that this contributed to its collapse. The ulema, fearing a similar fate [as the Janissaries] offered the government no resistance. As Mansel put it, [the ulema] fearing similar annihilation if they opposed the government, [they] kept silent.xvii The Blessed Event was more revenge, than considered reform. As Cunningham notes, years later a British general watched with his own eyes as the Sultan supervised workmen striking the Janissary bonnets off gravestones in a Pera burial-ground.xviii Goodwin substantiating Cunninghams argument states: Janissary headstones, topped by the cocky turban of the order, were knocked over.xix Claims of acts of vengeance are supported by the eye-witness account of British Dragoman, Bartolomeo Pisani: Every corrner of the town is searched and every Janissary officer that is caught is conducted to the Grand Vizier and by him ordered to death [].xx The 1826 Janissary purge paved the way for further reform; without the Janissaries, the conservatives were powerless, and in a state of disarray. The abolition of the Janissaries impacted significantly upon Ottoman society. Suraiya Farooqhi et al propose that in Constantinople, the destruction of the Janissary corps had economic and social, as well as political implications: in Istanbul [Constantinople] and many other cities, the Janissaries had played a crucial role in the Ottoman urban economy.xxi According to Maksudoglu, many shopkeepers held paid Janissary posts.xxii The Anglo-Turkish Convention (1838) abolished protectionist policies. Charlotte Jirousek, an expert in consumption studies, agrees that the convention formally established a policy of free trade and removed the longstanding protections on domestic manufacturers.xxiii Suraiya Farooqhi et al argue that the 1838 Anglo-Turkish Convention eliminated state monopolies and removed many of the barriers in the way of European merchants.xxiv The convention had a devastating impact on Ottoman manufacturers and craftsmen, Mansel agrees that the convention opened the empire to a flood of British goods and ruined many Ottoman crafts.xxv The destruction of the Janissary corps (1826) and the Anglo-Turkish Convention (1838) further integrated Ottoman and European economies, just as the 1839 Tanzimat decree more closely aligned the Middle Eastern with Western political structures. Mansel argues, it was the Sultans reason and his determination to save his monarchy, which drove him to modernise.xxvi Ahmad suggests that the reformers had become more convinced that the empires penetration by industrial Europe and its absorption into the expanding world market was the only way for the empire to survive and prosper.xxvii Though a valid argument, attempting to achieve absorption into the world market without first addressing pressing domestic social concerns deemed the economic reforms counter-productive. Mansel agrees, as a result of the 1838 treaty, beggars became more common on the streets of the city [Constantinople].xxviii Glenny cites a failure to industrialise as a principle cause behind the empires collapse. Though his argument is understandable, it isnt entirely accurate. There were attempts to industrialise, in so far as to mirror European industrial development. According to Mansel, the phrases English standards and European standards were constantly recurring in official letters. xxix The Armenian Dardian dynasty was central to the Ottoman industrialisation process. Hovhannes Amira Dardian, an international entrepreneur visited England and France at government expense to study the latest industrial techniques and to purchase steam engines. In November 1831, the first Ottoman newspaper, Takvim-i Vekayi (Calendar of Events), or Moniteur Ottoman was printed in both Ottoman and French editions. Disagreement between Glenny and Mansel ought not to be seen as a weakness in my argument since Glenny is focusing specifically on the Ottoman guild system and not on general industrialisation. Between 1826 and 1839 the Ottoman Empire struggled to control key provinces; Kinross describes the empire as continuing to shrink in extent, retaining despite decay its internal organs while losing through disruption its outlying limbs.xxx Though, Maksudoglu argues that European powers decided to end Osmanli suzerainty over Greece.xxxi Disagreement between Kinross and Maksudoglu may be more apparent than real, since Maksudoglu, as he confesses, is founding his assertions primarily on Ottoman sources. European influence proved pivotal in inciting the territories to rise up against Ottoman governance. The War of Independence exposed the weaknesses of the Sultans reforms. As Mansel agrees, the Sultans reforms did not help the Ottoman Empire in its struggle against the Greek revolt.xxxii The War of Greek Independence began 25 March 1821 and is certainly one of the central elements in bringing about the case for reform. The War of Greek Independence, though initially taking the form of a Greek cultural renaissance, was in fact an attempt by the Greeks to actively destabilize the Ottoman Empire; as Glenny suggests: the Greek rebellions of 1821 were not spontaneous reactions to deteriorating social and economic circumstances.xxxiii By June 1827, after six years of war, the Ottomans under the leadership of the commander Reshid Pasha, succeeded in subjugating continental Greece, this ought to have signalled the end of the war, instead occupation of mainland Greece prompted British, French, and Russian intervention; the Russians, in particular, put immense pressure on the Ottomans. Maksudoglu, strengthening the line of argument, argues that the Russians were guilty of inciting the Greeks to revolt.xxxiv The Austrians under Metternich favoured the suppression of the rebellious Greeks. The British, encouraged by the ambassador Sir Stratford Canning, fought the Ottoman government. According to Mansel, in an effort to persuade the Ottoman government to recognise Greece, European ambassadors, who felt physically threatened in Constantinople, left for the island of Poros between December 1827 and June 1829.xxxv On 20 October 1827, the Ottoman fleet was completely obliterated at the Battle of Navarino. The support of British, French and Russian navies for the Greeks insurgents violated the 1827 Treaty of London in which the three great powers had committed themselves to securing an armistice between the Greeks and the Ottomans, without taking part in the hostilities between contending parities.xxxvi The British, as suggested by Glenny, were egged on by the philhellenic sentiments of Sir Stratford Canning.xxxvii Kinross agrees: the great powers, the rival expansionist empires of Austria-Hungary and Russia, intrigued from behind their adjoining frontiers, marking out spheres of influence, stirring up satellites, and preparing to move when the moment was ripe.xxxviii The great powers crucially interfered in the affairs of the Ottoman provinces, destabilising the empire. Agreement between Glenny and Kinross reinforces the argument. In 1832, the Ottoman Army was convincingly defeated in Syria by Mehmet Alis Egyptian army led by his son, Ibrahim Pasha. The Sultans new army made up initially of ex-Janissaries, proved just as ineffective. Kinross describes the Sultans new troops as being not yet a match for so practiced an enemyxxxix. Marshal Marmont, a former marshal of Napoleon I and Charles X proclaimed: they are not troops; they are a reunion of men the character of whose general appearance is a miserable and humiliated air. It is clear that they are aware of their weakness.xl Agreement between Kinross and Marshal Marmont strengthens the argument that the 1826 Janissary purge was, to a large extent, a failure. The Sultan succeeded in getting rid of the Janissaries, but failed to effectively replace them. As Count Helmuth von Moltke, who in 1835 was brought from Prussia to train the army, put it: it was indispensable for him to clear the site before setting up his own building. [] The first part of his great tas k the Sultan carried through with perspicacity and resolution; in the second he failed.xli From the outset, Mehmet Ali was a thorn in the side of the Sublime Porte, as Kinross put it, he was the Sultans menacing vassalxlii. The Sultan was forced to turn to the Ottomans traditional enemies, the Russians. According to Kinross, this was because British Foreign Secretary Lord Palmerston, who at the time was pursuing a policy of retrenchment of his armed forces, rejected his plea for aidxliii. Though on the other hand, Lord Ponsonby is said to have accused the Sultan of throwing his crown into the lap of the Emperor Nicholas and reminded him of the power of the British to stop the Russians and Mehmet Alixliv. In 1840 the British forced Ibrahim Pasha from Syria and bombarded Alexandria. Mehmet Ali pulled his troops out of Crete and Arabia and accepted the hereditary governorship of Egypt. By 1839 the Ottoman Empire had significantly deteriorated. The Tanzimat decrees (1839) were issued in exchange for support in Egypt. As Goodwin argues, in 1839, in return for the powers putting pressure on Mehmet Ali to accept hereditary governorship of Egypt, he issued [] a reformist charter.xlv Kinross describes the reforms beginning in 1839 as nothing less than the transformation of Turkey from a medieval empire, based on the principles of Islam into a modern constitutional state, based equally on the secular principles of the West.xlvi The assertions of both Goodwin and Kinross strengthen my argument; the Tanzimat issued in secular principles, although it was promulgated in order to receive foreign support in Egypt. Western powers used the artificial doctrine of nationalism as a means by which to incite the non-Muslim citizens of the empire to rebel against the Government. As Goodwin put it, nationalism was a pretence.xlvii My argument is strengthened by Maksudogluxlviii, Eccleshall et al, and in part, by Glennyxlix. Kinross adds, inspired by nationalist feelings, they sought to break free of the empire and carve up the country between them.l According to Goodwin, the Philhellenic movement is often accredited with being responsible for revitalising the Greek spirit and alerting the western governments to the suffering of the empires Greek Christians. This argument is both misleading and certainly untrue. The majority of the Philhellenes were more driven by personal greed than by a desire to see Greek independence; all observers, both Greek and non-Greek, exempt Lord Byron from this criticism. Glenny also points out that: Turkish rule over parts of Greece was no longer viable.li The tributes paid to Byron after his death, by both European politicians and literary figures pressured the British government to adopt a more interventionist stance.lii Most historians agree that the preservation of the Ottoman Empire was in the best interests of the great powers. According to the British Foreign Secretary Lord Castlereagh, barbarous as it is; Turkey forms in the system of Europe a necessary partliii. Wellington declared: The Ottoman Empire stands not for the benefit of the Turks but of Christian Europe.liv A Russian secret government committee in 1828 came to the conclusion that the advantages of the preservation of the Ottoman Empire outweigh its disadvantages (since it would probably be replaced by powers under influence of Britain or France).lv In the context of nineteenth century Europe, the preservation of the Ottoman Empire was a necessity for the great powers, but only in the sense that it was essential that the empire didnt come under rival control. The agreement between Castlereagh and Wellington focuses specifically on retaining the balance of power, and not on preserving the empire as a goal in and of itself. In conclusion, the reforms passed in the period 1826-1839 significantly contributed to the empires collapse. Although the Janissary purge, as argued by Ahmad and Mansel, was necessary as they were no longer effective; without them, the Sultan was allowed to accumulate debt unhindered. Debt led to inflation, soaring food prices and general discontent. The ulema, fearing similar treatment [as the Janissaries] were forced to remain silent. The Janissary purge failed to cure the problem of an ineffective army, and merely served to avenge the acts of disorder carried out by the corps. Without the Janissaries, and with the ulema now impotent, there was no defence against harmful reform e.g. the 1838 Anglo-Turkish Convention flooded the empire with British goods and ruined many Ottoman manufacturers, other reforms, though not necessarily harmful, proved nevertheless ineffective. As Kinross points out by Metternich and others [] [they] were cynically dismissed as an essay in window dressing.lvi If it were not for the Janissary Purge, then it is possible that the empire would have been in a better position to defend itself against foreign intervention and the Sultans excesses. i Suraiya Farooqhi, Bruce McGowan, Donald Quartaert and Serket Pamuk An Economic and Social History of the Ottoman Empire Volume II 1600 1914 Cambridge University Press (1994) 2 Feroz Ahmad, The Making of Modern Turkey, Routledge (1993) iii E.Eldem, Pride and Privilege: A History of Ottoman Orders, Medals and Decorations, Istanbul (2004), p35 iv Stanford J. Shaw, History of the Ottoman Empire and Modern Turkey, Cambridge University Press (1991) 5 Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), pxxv vi Stanford J. Shaw, History of the Ottoman Empire and Modern Turkey, Cambridge University Press (1991), pvii vii Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), p238 viii Feroz Ahmad, The Making of Modern Turkey, Routledge (1993), p24 ix Anonymous, quoted in Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p256 10 Feroz Ahmad, The Making of Modern Turkey, Routledge (1993), p24 xi Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p238 xii Ibid p249 13 Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), p.292 14 R.G.Grant, Battle a visual journey through 5,000 years of combat, DK, (2005), pg34 xv Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), p214 xvi Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), p311 xvii Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p274 xviii Allan Cunningham, Anglo-Ottoman Encounters in the Age of Revolution, (1993), p34 xix Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), p298 xx Bartolomeo Pisani, quoted in, Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p238 21 Suraiya Farooqhi, Bruce McGowan, Donald Quartaert and Serket Pamuk An Economic and Social History of the Ottoman Empire Volume II 1600 1914 Cambridge University Press (1994) xxii Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), p209 xxiii Charlotte Jirousek The Transition to Mass Fashion System and Dress in the Later Ottoman Empire p213-230 Donald Quartaert, editor Consumption Studies and the History of the Ottoman Empire xxiv Suraiya Farooqhi, Bruce McGowan, Donald Quartaert and Serket Pamuk An Economic and Social History of the Ottoman Empire Volume II 1600 1914 Cambridge University Press (1994) xxv Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p258 xxvi Ibid, p250 26 Feroz Ahmad, The Making of Modern Turkey, Routledge (1993), p24 xxviii Ibid p258 xxix Ibid p254 xxx Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977), p.440 xxxi Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), p210 xxxii Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p247 xxxiii Misha Glenny, The Balkans 1804-1999 Nationalism, War and the Great Powers, (Granata Books), London (1999) p26 xxxiv Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), p208 xxxv Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p248 xxxvi The Treaty of London (1827), quoted in, Misha Glenny, The Balkans 1804-1999 Nationalism, War and the Great Powers, (Granata Books), London (1999) p34 xxxvii Ibid xxxviii Lord Kinross, Ataturk A biography of Mustafa Kemal, father of modern Turkey, William Morrow and Company, New York, (1978), p8 xxxix Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977), p467 xl Marshal Marmont, quoted in Phillip Mansel, Constantinople City of the Worlds Desire 1453-1924, John Murray (Publishers), (1995), p259 xli Count Helmuth von Moltke, quoted in, Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), p302 xlii Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977), p467 xliii Ibid p468 xliv Phillip E. Moseley, Russian Diplomacy and the opening of the Eastern Question in 1838-1839, Harvard, (1934), p78 xlv Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), pg304 xlvi Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977), p440 xlvii Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998), pg295 xlviii Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999), p207 xlix Robert Eccleshall, Vincent Geoghegan, Richard Jay, Rick Wilford, Political Ideologies, Unwin Hyman, London (1990) l Lord Kinross, Ataturk A biography of Mustafa Kemal, father of modern Turkey, William Morrow and Company, New York, (1978), p8 li Misha Glenny, The Balkans 1804-1999 Nationalism, War and the Great Powers, (Granata Books), London (1999) p35 lii Ibid, Lord Castlereagh liii Ibid p248, The Duke of Wellington liv Ibid lv Ibid lvi Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977), p475 Bibliography Feroz Ahmad, The Making of Modern Turkey, Routledge (1993) Allan Cunningham, Anglo-Ottoman Encounters in the Age of Revolution, Routledge (1993) Robert Eccleshall, Vincent Geoghegan, Richard Jay, Rick Wilford, Political Ideologies, Unwin Hyman, London (1990) E.Eldem, Pride and Privilege: A History of Ottoman Orders, Medals and Decorations, Istanbul (2004) Suraiya Farooqhi, Bruce McGowan, Donald Quartaert and Serket Pamuk An Economic and Social History of the Ottoman Empire Volume II 1600 1914 Cambridge University Press (1994) Misha Glenny, The Balkans 1804-1999 Nationalism, War and the Great Powers, (Granata Books), London (1999) Jason Goodwin, Lords of the Horizons A History of the Ottoman Empire, Chatto Windus, London, (1998) R.G.Grant, Battle a visual journey through 5,000 years of combat, DK, (2005) Halil Inalcik, The Ottoman Empire; The Classical Age 1300-1600, London (1973) Charlotte Jirousek The Transition to Mass Fashion System and Dress in the Later Ottoman Empire Donald Quartaert, editor Consumption Studies and the History of the Ottoman Empire State University of New York Press (2000) Lord Kinross, Ataturk A biography of Mustafa Kemal, father of modern Turkey, William Morrow and Company, New York, (1978) Lord Kinross, The Ottoman Centuries: The Rise and Fall of the Turkish Empire, Morrow Quill Paperbacks, New York, (1977) Mehmet Maksudoglu, Osmanli History 1289-1922, International Islamic University, Malaysia (1999) Phillip E. Moseley, Russian Diplomacy and the opening of the Eastern Question in 1838-1839, Harvard, (1934) Stanford J. Shaw, History of the Ottoman Empire and Modern Turkey, Cambridge University Press (1991)

If Division by Zero Were Allowed Essay Example for Free

If Division by Zero Were Allowed Essay Division is a basic mathematical operation by which we divide a number called dividend by another number called the divisor. This division functions is very simple and is the base of many complex mathematical functions. But there’s a very simple division which is indefinable, and that is the division of a number by zero, which is indefinable. We have been studying through out student life that division of a number is indefinable (infinite). But still if division by zero were allowed than what kind of impacts it would have on our daily lives and surroundings? If this were allowed it would open new breakthroughs in the realm of science, and also at the same time start many confusions and errors. The world of science and technology would be going under a serious and altering change, having deep impact on almost anything related to these fields. Impact on Mathematics: Mathematics revolves around its basic operations, addition, subtraction, multiplication and division. All complex and simple mathematical operations include the above basic operations. With out them solution would not be possible. It has been ruled out that division of a number by zero is indefinable (infinite). By infinite we mean that it cannot be defined Let us suppose if we temporarily allow this what kind of possibilities what would we get? Let’s take a simple example in which we take the following case. Let us consider the following equations, A/B = C We can consider A = 9 B = 0 Then the above equation can be written as, 9/0 = C If we consider division by zero as possible then we can make the following changes, 9 = 0*C 9 = 0 Now from the above example we have just considered the possibility that a number can be divided by zero and taking this hypothesis we moved forward with its testing, but in the end a very baffling result is achieved: 9 = 0 This is not possible because the number 9 is something substantial and an amount which cannot be nullified in an instant. Hence this proves that whenever a there’s division by zero there will always be an anomaly, and so it can be inferred that the answer given will always be impossible. Impacts on Technology: Our technologically advanced world is based on computer technology. The computer contains an Arithmetic Logic Unit (ALU). This unit handles all the mathematical operations performed in a computer. Even the computer programs are based on these operations. Computers can’t divide anything by zero, because they have been programmed not to do so. So if a computer were ever to divide something by zero we would be in big trouble keeping in view the original programming of the computers. Just imagine this possibility, world wide computer crashes would occur. Chaos would spread by the loss of data. Planes, satellites, appliances would not work. Imagine what kind of life would be there. Navigational equipment might not work properly which could lead to many disasters like airplane crashes, accidents. This has happened before when On September 21, 1997, a divide by zero error in the USS Yorktown caused all the computer system on the ship to malfunction and the boat stopped in the middle of an ocean . In the present situation of our technological development, we are dependent on our computers and other such gadgets so a loss of them would be a major blow overall. Impacts on Physics: When we study physics we may get many laws and mathematical theories in which division of a quantity with the other is made. In all these laws whenever we face a problem of division of a physical quantity with zero, we always infer it as infinite. If this zero division would be made possible the current laws would be changed as to impossible to exist in actual. We take an example of Density. Mathematically, D = m/v (Density D, mass m, volume v) We assume that volume (v) goes to zero, D = m/0 If this division is possible we can write above as, D*0 = m This would give, 0 = m This is not possible as per Law of Conservation of Mass, which states matter can neither be created nor destroyed. Again it was seen that division by zero is ambiguous and if allowed it would lead to the impossible and impractical results. In the above stated example we clearly see that a mass can never be zero, the reason being is that a mass is weight and for it to exist it would have to have some weight and thus it is proved that it can’t be divided. Impact on Commerce and Banking: If a bank employee or computer accidentally divides your bank balance by zero think what would happen. Wouldn’t your balance become something inexhaustible? You could use all the money available in the world and not be aware of it. Similarly in commerce, if during purchase buying of goods this mistake would occur. Either the purchaser or the seller would face bankruptcy. So the worst possible economic chaos would be occurring in the field of commerce and banking sector as only a sole party, either the bank or individual consumers, would be facing all the burden and humiliation of the bankruptcy.

Role Of Chromosome 21 In Alzheimers Disease Biology Essay

Role Of Chromosome 21 In Alzheimers Disease Biology Essay Down syndrome is a genetic disease that caused by trisomy of Human chromosome 21. Down syndrome is common chromosomal disorder of mental retardation in humans. It is caused by the three types of chromosomal abnormalities namely, free trisomy 21, translocation Down syndrome and mosaic Down syndrome. Most of the Down syndrome individuals experience Alzheimer-like neuropathology like dementia, neurofibrillary tangles and many others. Genes that are in Chromosome 21 which includes SOD-1, DSCR1, APP gene and S100B, are highly involved in the relationship between Down syndrome and Alzheimer disease. Besides the genes involved, other factors like oxidative stress and hormone will be discussed in this review too. There are two different types of hypotheses associated with Down syndrome namely, developmental instability and gene-dosage effect. Introduction Down syndrome is a common chromosomal disorder of mental retardation in humans. It is caused by the trisomy of chromosome 21. Down syndrome is named after John Laugdon Down in 1866.There is three different types of chromosomal abnormalities namely, free trisomy 21, translocation Down syndrome and mosaic Down syndrome. Over 90% of the time, non disjunction and failure to separate the chromosome pairs during meiosis are the principal cause of Down syndrome. Down syndrome is named after John Laugdon Down in 1866. The first person that published the relationship between Alzheimers disease-type neuropathology to clinical dementia in adults with Down syndrome was Jervis in 1948 and the person to demonstrate this disorder is due to the trisomy of chromosome 21 was by Jerome Lejeune in 1959. The symptoms associated with Down syndrome are diminished muscle tone, congenital heart disease, small skull, slanting eyes and retarded growth and development. Individuals with Down syndrome usually hav e the tendency of developing neuropathological changes like Alzheimer disease. Down syndrome has an overall incidence of 1 in 1000 live births when the mother aged 30, increasing 9 in 1000 births when the mother is aged 40 (Hook et al., 1983). Alzheimer disease is a neurodegenerative disease which maybe is found in Down syndrome individuals. This disease is named after a neuropathologist, Alois Alzheimer in 1906. Down syndrome individuals experience the Alzheimer-like neuropathology by their mid-40s. In the beginning, Alzheimer disease affects parts of brain like memory and languages. But after a period of time, this disease will progress and cause problems in all aspects of our life. Alzheimer disease has 2 forms, familial and sporadic forms. Familial Alzheimer disease is a rare disease which is genetically acquired. There are mainly 3 types of lesions that are observed in Alzheimer disease. It is then caused by the mutations in several genes like APP which will lead to the over production of the amyloid-beta protein. The most common form of Alzheimer disease is sporadic form which contributes to 90% of Alzheimer disease cases. The first type is the neuritic plaques, extracellular deposits of fibrillar beta amyloid surrou nded by degenerating neuronal processes and terminals. The next type of lesions is intraneuronal neurofibrillary tangles, primarily composed of abnormally hyperphospholated tau protein and lastly, it is vascular beta-amyloidosis associated with fibrillar amyloid deposition within the vascular wall. Over time, these pathological processes contribute to synaptic and neuronal loss, deterioration of neuronal networks, brain atrophy and dementia (Victor Ropper, 2001). Nowadays, people have longer life span and hence the Alzherimer disease become much more worrying for us as it will become a major public concern. There were 26.6 million of people that are suffering of the Alzheimer disease in 2006 and this number will continue to grow. It is then estimated to affect 1 in 85 people worldwide by the year of 2050. In fact, it was not until 1985 that research explicitly focused on aging related changes in health status and cognition of adults with intellectual disabilities, and in particular those with Down syndrome, began in earnest (Janicki et al, 1985). In Down syndrome, there are two different types of hypotheses associated namely, developmental instability and gene-dosage effect. The developmental instability hypothesis indicated that the correct balance of gene expression in the development is being disrupted. But this hypothesis is being questioned since other autosomal trisomy syndromes do not lead to the same clinical pattern (Shapiro et al,2001). In another case, the gene-dosage effect hypothesis, specific gene that is over expressed is responsible for the Down syndrome phenotypic abnormalities which indicated is trisomy of the Chromosome 21 (Delabar et al,1993). The Genes In chromosome 21, the most critical part that affects Down syndrome phenotype is the long arm(q) of chromosome 21. The critical region in chromosome 21 that is important to Alzheimer disease are amyloid precursor protein (APP) located at Chromosome 21q21.3 , superoxide dismutase gene (SOD-1) located at Chromosome 21q22.11, Beta-site APP-cleaving 2 enzyme (BACE2) located at Chromosome 21q22.3, carbonyl reductase (CBR) located at Chromosome 21q22.1 and cystathionine beta-synthase (CBS) located at Chromosome 21q22.3 . The critical region in chromosome 21 that is important to Down syndrome are glycinamide formyl transferase (GART) located at Chromosome 21q22.1, SOD-1, Cu2+/Zn2+ superoxide dismutase, beta subunit of S100 calcium-binding protein (S100B) located at Chromosome 21q22.3, Down syndrome critical region gene 1 (DSCR1) located at 21q22.3 and Intersectin 1 (ITSN1). The Amyloid precursor protein (APP) APP gene is located on human chromosome 21 and codes for a transmembrane protein that is expressed in both neurons and astrocytes. This gene is important in the relationship between Down syndrome and Alzheimer disease. Overexpression of APP gene will lead to the increase production of amyloid-beta protein which is the main protein component of senile plaque. The cause of the familial Alzheimer disease is by the mutation n the APP gene. The amyloid-beta protein is formed by the proteolytic cleavage of the large, type-1 integral membrane-spanning glycoprotein APP by secretases. It has two different pathways, the amyloidogenic pathway and the nonamyloidogenic pathway. The amyloidogenic pathway is beta-secretase cleaves APP to generate APPsB, a 100-kDa soluble NH2-terminal fragment and a 12-kDa membranebound carboxyl-terminal fragment. Hence, the nonamyloidogenic pathway is that cleaved within its amyloid-beta region (aminoacids 16-17), at the alpha-secretase cleavage site, to produce an N-terminal fragment, APPsa, and a C-terminal APP fragment of 83 amino acids (Kang et al,1987). In normal mechanism of the brain, there is stable distribution of beta-amyloid in the brain and this intracellular beta-amyloid is essentially in the entire life indicated that beta-amyloid within neurons represents a product of normal metabolism. The two most common species of beta-amyloid are AB40 and AB42. Beta-amyloid will start to accumulate during younger times and with increasing in age, the amount will progressively increase. During middle ages like 35 years, beta-amyloid associated neuropathology will accelerate tremendously. The soluble APP is the most toxic APP which can have neurotrophic activities and longer aggregating forms. The amyloid-beta protein at high concentration will lead to neurotoxic whereas at low concentration it can function as a neurotrophic factor. When amyloid-beta protein is oxidized, the solubility will decrease and hen will result in the accumulation of the intracellular microglial. This accumulation will increase the concentration of amyloid-beta protein and lead to more plaque formation. Amyloid-beta protein will also induce oxidative stress directly and activating microglia indirectly (Yankner et al, 1990). Although it has been a strong standing that amyloid-beta protein contributes to the Alzheimer disease but there is evidence that amyloid-beta protein is very useful in our body. Amyloid-beta protein provides an important role in both synapse and in synaptic structure-functional plasticity that underlie learning and memory (Koudinov et al, 2001). The autopsy studies in brains of older Down syndrome individuals showed that senile plaque and neurofibrillary tangles and in the brains and some indivuals show a much earlier onset. This maybe suggest that there is an apoptotic action happening and may result in the large amount of neuronal death in the brain. It has been studies to show that APP metabolism in involved in the peripheral tissues. Changes occurs in APP metabolism is noted in the platelets, lymphocytes and fibroblasts in both Down syndrome and Alzheimer disease individuals. This change in APP showed that there is two to three fold of increase plasma concentration in both amyloid-beta protein(1-40) and amyloid-beta protein(1-42) in Down syndrome individuals and also increase of mRNA of APP. The Beta-site APP-cleaving 2 enzyme (BACE2) BACE is a transmembrane aspartyl protease and has a second protein called BACE2 that is 55% identical to BACE.BACE2 has two active site motifs of aspartic protinases which are located at residues 93 to 96 of DTGS and residues 289 to 292 of DSGT. BACE2 has a minor cleavage site at the beta-site of APP and also a major cleavage in the beta-amyloid region that is close to the alpha-secretase site. BACE2 is said to contribute to the amyloid-beta protein production. Some authors investigate the expression of BACE2 in the frontal context of the Down syndrome patients and hence, the immunoreactivity of BACE2 in Down syndrome patients with Alzheimer disease and control is compared. The results show that in neurorofibrillary tangle-bearing neurons there is BACE2 but not in those Down syndrome patient without Alzheimer disease. So, this will give an indication that BACE2 contribute to the Alzheimer-type neuropathology of Down syndrome (Barbiero et al, 2002). In Alzheimer individual platelets, there is a significant amount of reduction in the BACE2 which suggest that this BACE2 cause increase Alzheimer neuropathology. The Down syndrome critical region gene 1 (DSCR1) and The Intersectin 1 (ITSN1) The DSCR1 gene is located at the human chromosome 21 and it encodes for the calcipressin 1 which inhibit calcineurin activity by interacting with calcineurin A. So, phosphorylation of calcipressin 1 will inhibit the activity of calcineurin and this will allow the control the half life of calcipressin by increasing its degradation. To protect the cells from getting damaged, negative feedback mechanism of DSCR1 gene should be activated. In brain, heart and skeletal muscle, the DSCR1 is highly expressed. It was shown that DSCR1 is over expressed in the individual brain of the Down syndrome fetuses and post mortem and for those Alzheimer disease individuals, they also showed DSCR1 mRNA levels to be two to three times higher than the control. Basically, overexpression of DSCR1 can affect two calcineurin-dependent pathways by blocking calcineurin activity. So, when there is an increase of DSCR1, it may disrupt endocytosis and the vesicle recycling because of the calcineurin-dependent dephosphin dephosphorylation. Next, the hyper The ITSN1gene is located in human chromosome 21 and it encodes for endocytic protein ITSN1. In this gene, there are two major mRNA transcripts which divided into 6kb and 11kb, short and long isoforms. These isoforms are expressed in the brain but in different cell types. It has been detected in western blotting that long form is neuronal specific while the short form is in glial cells and for those Down syndrome individual, there is an over expression of the long isoform in the brain. These genes are involved in the neruronal endocytosis in the pathology of the Down syndrome and Alzheimer disease. In neuronal endocytosis, it is very important for the neuronal repair and survival as the secretory vesicles need to be reuptake during the synaptic transmission after any neuronal damage. The Minibrain-Kinase Gene The gene minibrain-kinase maybe associated with Down syndrome. This gene is encoded to the Down syndrome critical region 21q22.2. There has been studies that showed that the over expression will cause congnitive impairments with Down syndrome and increases in apoptotic cell death and reduction in neuronal differentiation which altered neuronal plasticity and intellectual disability observed in Down syndrome (Murakami et al, 2006). The Immune System Astrocytes also play an important role in old Down syndrome patients brain. Upon activation in the brain of the Down syndrome patient, it will express more of the S100B, an astrocyte-derived neurite growth-promoting factor. S100B is associated in dystrophic neurite formation and in plaque evolution and also in neurofibrillary tangle evolution in Alzheimer disease. S100B is secreted by astrocytes and increase the intraneuronal free calcium levels and stimulates the growth of neuronal processes. In the studies of S100B, it showed that the number of astrocytes expressing S100B in Down syndrome patient was about twice as that to the controls of all ages. Another way to test for the relationship between Down syndrome and Alzheimer disease is by the complement cascade, C1q. C1q accumulates in amyloid-beta protein deposits in neurons within Down syndrome brain. In this case, the increase level of C1q will suggest that it is responsible for the acceleration phase of Alzheimer disease pathogenesis in Down syndrome patient (Stoltzner et al, 2000). The Oxidative Stress Another factor that is involved in both Alzheimer disease and Down syndrome is oxidative stress. As we all know that oxygen is very important for life but the byproducts are very harmful. These byproducts include reactive oxygen species like superoxide and hydroxyl and hydrogen peroxide and peroxynitrite (Andersen et al.,2004). The amyloid precursor protein and the cytoplasmic enzyme Cu2+/Zn2+ superoxide dismutase (SOD-1) are responsible for reactive oxygen species homeostasis. SOD-1 is responsible for the first line of antioxidant defense by catalyzing the dismutation of O2à ¢Ã¢â€š ¬Ã‚ ¢- to molecular oxygen (O2) and H2O2, which can be converted by catalase (CAT) and by (selenium-containing) glutathione peroxidase (GPX) to water. Since SOD-1 is located at chromosome 21, so the trisomy of chromosome 21 will lead to accumulation of hydrogen peroxide because of the imbalance in the ratio of SOD-1 to CAT and GPX. Hence, this will lead to the increase of neuronal cell death which also c ontributes to the progressive mental decline in both Down syndrome and Alzheimer disease. In peripheral tissues, SOD-1 has 50% more in patients than normal in the immune system. Hence, it will disrupt the immune system to make the patients to be weaker (Benzi et al, 1997). The E2F-1 Gene The E2F-1 gene is located in human chromosome 20. It encodes a protein E2F-1 transcriptional factor E2F-1. This transcription factor plays major role in in the control of cell cycle, action of tumor suppressor proteins and DNA damage to apoptosis. The ETS2 Gene The ETS2 gene is located on human chromosome 21q22.2. This gene encodes for a protein Protein C-ets-2 which is a transcriptional factor of beta-APP gene. It will specifically bind to the beta-APP promoter and work with transcription factor AP1 (Wolvetang et al, 2003). The Oestrogen Hormone Oestrogen has a role of protecting neurons from the toxic effect by amyloid-beta , ameliorated the cerebral metabolism and also increase the level of acetylcholine in the basal forebrain and hippocampus. It also has the antioxidant effect which is very helpful towards Alzheimer disease. Other beneficial impacts include reduction of the lipid peroxidation, prevention intracellular peroxide accumulation and reduce the degradation of the neurons in the brain. So, it is said that estrogens reduce the occurrence of Alzheimer disease of Down syndrome woman. Woman patients with Down syndrome may have an earlier occurrence or more serve form of Alzheimer disease when these women has early onset of menopause compared to those late menopause women (Schupf et al., 2006). But those post-menopause women that receive estrogen replacement therapy may have a lower occurrence in having Alzheimer disease. The Apolopoprotein E Gene Another factor that attribute to the late onset of Alzheimer disease is Apolopoprotein E (APOE) gene. This gene is located on chromosome 19 and has 3 types of alleles (Corder et al., 1993). The allele that is responsible for Alzheimer disease is APOE ÃŽÂ µ4 allele. It is found that patients with Alzheimer disease has higher frequencies of the APOE ÃŽÂ µ4 allele compared with those without other APOE genotypes and have a earlier onset of Alzheimer disease (Corder et al., 1993). Another allele that has good contribution towards Alzheimers disease for adults with Down syndrome is APOE ÃŽÂ µ2. It is the least common allele but can reduce the risk of Alzheimers disease for adults with Down syndrome (Schupf et al,1996). Cholesterol is transported by high-density lipoproteins such as APOE, and these suggested of the hypothesis that the relationship between APOE and risk of Alzheimers disease may be linked to cholesterol metabolism. Statins or HMG-CoA reductase inhibitors are currently the most widely prescribed class of cholesterol lowering medication. In a number of studies, it has been shown that the use of statin does reduced the risk of the Alzheimers disease. So, for participants with a total cholesterol level of 200 mg/dL or more, the effect of statin significantly lower the risk of dementia compared to that of other participants with lower total cholesterol (Green, Jayakumar, Benke, Farrer, 2002). The Sortilin-related receptor-1 Gene On chromosome 11 (11q24.1), there is this gene called sortilin-related receptor-1 gene (SORL1). It is a 250-kDa membrane protein that is expressed in the neurons of the nervous system. The SORL1 gene has the role of intracellular trafficking between membrane and hence, interacting with amyloid precursor protein (APP) in endosomes and golgi. This gene function to get rid the excess beta amyloid protein. So, when there is little expression of this gene, it will cause to the increase of beta amyloid protein hence it will lead to the accumulation of beta amyloid protein. Since there is already a large amount of beta amyloid protein in the brains of the Down syndrome patients, then it will have problem to decrease the amount of beta amyloid protein so it will increase the risk of having Alzheimer disease. (Rogaeva et al, 2007) The Phorsphorylation Phosphorylation is a mechanism that controls the activity of enzymes and receptors by switching on the regulation of the cell function. Constant activation of the phosphorylation mechanism will increase the accumulation of the of neurofibrillary tangles, abnormal twisted protein filaments that form within affected neurons and are composed mainly of hyperphosphorylated tau protein (Hardy et al, 1991). So, the hyperphosphorylated tau protein in the brain of the transgenic mice with extra human minbrain-kinase gene also give us the indication of the overexpression of minibrain-kinase could contribute to the early onset of Alzheimers disease associated with Down syndrome ( Wegiel et al, 2008). The Age There have been studies that suggest that overall dementia risk increases beginning in the late 40s or early 50s and even some twenty years earlier than it does within the general population. However, there is still some individuals vary on the onset age. A small minority of adults with Down syndrome begin to experience substantial declines in cognition before age 50, yet another minority is able to mature well into their late 60s or early 70s without experiencing signs or symptoms of Alzheimers disease (Schupf, 2002). There are studies on the different ages of mothers who give birth to their children to have risk of having dementia. The results showed a four-fold increase in risk of dementia among mothers who gave birth to their children with Down syndrome less than 35 years of age compared with mothers who were older than 35 years when their child with Down syndrome was born or compared with mothers of children with other intellectual disabilities (Schupf et al., 1994). The Biomarkers Biomarkers are used to monitor diseases progression so it is very useful in quantifying the effects of any available treatment regimen. Because biomarkers are strongly associated with disease risk, detection of early changes in biomarker levels provides an opportunity for early intervention to delay or prevent disease onset (Lesko Atkinson, 2001). To date, validated biomarkers for Alzheimers disease in adults with Down syndrome have yet to be discovered. However, there are some biomarkers that have been investigated. These include measures of the quantity and type of beta amyloid protein found in blood plasma and telomere size in metaphase and interphase preparations as well as on individual chromosomes (Schupf, Patel et al., 2001). There is a close relationship between Down syndrome and Alzheimer disease mainly cause by the overexpression of the APP gene and lead to the over production of the protein, amyloid-beta protein(1-40/42), the major contribution to Alzheimer disease pathogenesis in Down syndrome patient. It is reported in both cross-sectional and prospective analyses that beta-amyloid 1-42 levels increased in demented adults with Down syndrome but not beta amyloid 1-40 levels. For people who are nondemented but with high plasma beta-amyloid 1-42 levels were over two times as likely to develop Alzheimers disease as those with lower levels (Schupf, Patel et al., 2001). Telomeres are DNA sequences that located at the end of the chromosome which is a series of repeats of the TTAGGG nucleotide sequence. These DNA sequences undergo shortening with each cell division, serving as markers of a cells replicative history and an indicator of cellular aging. Using quantitative telomere protein nucleic acid fluorescent in situ hybridization (FISH) analyses of metaphase and interphase preparations from age matched pairs of participants with Down syndrome with and without dementia, there are four observations being observed. The first observation is there are shorter telomeres in individuals with dementia. Next, the individual chromosomes 1 and 21 could be used alone and/or in combination to detect telomere shortening. The third observation is that the cells from individuals with dementia or MCI had reduced numbers of telomere signals when analyzed using a PNA telomere probe, and lastly the shorter telomeres in individuals with MCI (Jenkins, Velinov, Ye, Gu, Li et al., 2006). The Conclusion In conclusion, Down syndrome showed that it has a relationship with the pathology of Alzheimer disease. Triplication of chromosome 21that causes over expression of the amyloid-beta protein is the major cause towards the pathology of Alzheimer disease. Not only so, some other sub factors also contribute to it. After understanding the various causes that resulted in Down syndrome patients to have Alzheimer disease, it will be easier for us to invent more ways to treat all these symptoms and hence it will definitely benefit a lot of people that are associated with these diseases.

Analysis of Mary Reilly by Valerie Martin Essay -- Mary Reilly Valerie

Analysis of Mary Reilly by Valerie Martin The book Mary Reilly is the sequel to the famous The Strange Case of Dr. Jekyll and Mr. Hyde. The Strange Case of Dr. Jekyll and Mr. Hyde by Robert Louis Stevenson, is a stark, ingeniously woven, engaging novel. That tells the disturbing tale of the dual personality of Dr. Jekyll, a physician. A generous and philanthropic man, his is preoccupied with the problems of good and evil and with the possibility of separating them into two distinct personalities. He develops a drug that transforms him into the demonic Mr. Hyde, in whose person he exhausts all the latent evil in his nature. He also creates an antidote that will restore him into his respectable existence as Dr. Jekyll. Gradually, however, the unmitigated evil of his darker self predominates, until finally he performs an atrocious murder. His saner self determines to curtail those alternations of personality, but he discovers that he is losing control over his transformations, that he slips with increasing frequency into the wo rld of evil. Finally, unable to procure one of the ingredients for the mixture of redemption, and on the verge of being discovered, he commits suicide. Mary Reilly by Valerie Martin, is a powerful and moving novel. It takes the story Dr. Jeckyl and Mr. Hyde, and gives a fresh take on the distinguished Dr. Henry Jekyll and the nefarious Mr. Edward Hyde. It is told through the psyche of a Victorian servant named Mary Reilly. The book's structure purports to be Mary Reilly's diary. The entries articulate Mary Reilly's feelings and experiences while in service for Dr. Henry Jekyll, and how she often empathizes with Dr. Jekyll on his afflictions which she cannot comprehend. As the book progresses Mary Reilly continuously comments on her Masters every changing state of health. Towards the end of the book her mother passes away leaving Mary in grief. Soon after this personal catastrophe, she encounters Mr. Hyde while looking around out side. In this confrontation Mary is bitten on the shoulder by Hyde and is near death when Hyde abruptly ceases his frenzy. Not long after this the body of Mr. Hyde is found dead in Jekyll's laboratory. Naturally two books related to each other in this way have their similarities and differences in certain areas. Most of the similarities between both books fall in the areas of historical correctness and act... ...g, "The next morning I was washing the front steps when Mr. Poole came out the door and spoke to me very coldly. "The Master has sent for you to come to the drawing room," he said , and I knew he was displeased and suspicious, for Master never pays much attention to servants, and hardly knows their names, or so it seems, though that may be partly due to how determined Mr. Poole is to keep Master from any bother having to do with the house and what a free rein has over everything that goes on, including who is hired and let go." This long excerpt says that Poole monopolizes the master's attention, and has influence over the whole house and every thing in it, except for Master. Mary Reilly explained this sort-of servant dictatorship as if she accepted it, not because she had to, but because she was taught to. This excerpt made me feel badly for Mary Reilly because it showed that Mary was content with her life. This is upsetting to me because I think that Mary had potential to be a successful writer rather then a servant. Each excerpt said a totally different thing about the character Poole. Because of the difference of narrator in the descriptions how the excerpts were said is not

acupuncture :: essays research papers

Acupuncture The Chinese healing art of acupuncture is one that can be dated back at least two thousand years. Some authorities maintain that acupuncture has been practiced in China for even four thousand years. Though its exact age is vague, what is certain is that up until the recent twentieth century, much of the population of the world was uninformed about acupuncture, its origins, and its capacity to promote and maintain good health. Even today in relatively "advanced" nations such as the United States there are many who hold acupuncture under the stereotype of a new or radical medicine, one which would almost always be a second choice after more familiar Western approaches to handling illness. Acupuncture (and its related Moxibustion) are practiced medical treatments that are over 5,000 years old. Very basically, Acupuncture is the insertion of very fine needles, (sometimes in conjunction with electrical stimulus), on the body's surface, in order to influence physiological functioning of the body. The first record of Acupuncture is found in the 4,700 year old Huang Di Nei Jing (Yellow Emperor's Classic of Internal Medicine). This is said to be the oldest medical textbook in the world. It is said to have been written down from even earlier theories by Shen Nung, the father of Chinese Medicine. Shen Nung documented theories about circulation, pulse, and the heart over 4,000 years before European medicine had any concept about them. As the basis of Acupuncture, Shen Nung theorized that the body had an energy force running throughout it. This energy force is known as Qi (roughly pronounced Chee). The Qi consists of all essential life activities which include the spiritual, emotional, mental and the physical aspects of life. A person's health is influenced by the flow of Qi in the body, in combination with the universal forces of Yin and Yang Energy constantly flows up and down these pathways. When pathways become obstructed, deficient, excessive, or just unbalanced, Yin and Yang are said to be thrown out of balance. This causes illness. Acupuncture is said to restore the balance. Acupuncturists can use as many as nine types of Acupuncture needles, though only six are commonly used today. These needles vary in length, width of shaft, and shape of head. Today, most needles are disposible. They are used once and disgarded in accordance with medical biohazard regulations and guidlines. There are a few different precise methods by which Acupuncturists insert needles.

American Censorship of Japanese Animation Essay -- Television Media TV

American Censorship of Japanese Animation Abrstract: This essay will explore why Americans feel the need to censor Japanese Animation, how the Japanese culture differs from American culture, and how to solve the growing debate of the censorship of Japanese media.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Japan, that strange and exotic land in the east, has a complex and interesting history that has shaped and molded its culture into a very unique society today.   Of course their customs have influenced their entertainment, especially television and movies.   In a day and age where information is free to all through the internet and reliable postal systems these television shows, movies, toys, and comics have made their way all over the world.   The reception of Japanese media has had mixed reactions, both good and bad.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   America, being an amalgamation of societies and cultures, has naturally had a mixed reaction to Japanese media.   The younger generation, namely those in their twenties or younger, have embraced the bright and flashy style of Japanese animation.   The most popular shows are the ones with the most action, but shows that concentrate on character development and storyline are also popular, especially among the female population.   The older generation does not have such open minds unfortunately.   They do not seem to understand the appeal of the big eyed characters yelling nonsense at each other or the fact that all animation is not just silly kid’s stuff.   Not only that, but Japanese animation has been tagged as overly violent and obscene.   It has been accused of causing violence and disturbing young children by fundamentalist organizations.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   American television networks and video distributors also feel the need to c... ...they were truly meant to be, and parents do not have to worry about inappropriate content for their children.   With a little bit of effort the rising sun can be purified and enjoyed by all.   Works Cited Barker, Olivia.   â€Å"The Asianization of America.†Ã‚   USA Today.   March 2001: 1A-2A.     Ã‚   Infotrac.  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Bryant, Anthony J. and Arsenault, Mark.   Sengoku.   Gold Rush Games 1997-1999. Clements, Jonathon and McCarthy, Helen.   The Anime Encyclopedia.   Stone Bridge    Press 2001. Lazar, Jim.   â€Å"Anime Expo Report 2000.† www.animeprime.com Retrieved December 13, 2004. Lazar, Jim.   â€Å"Sailor Moon Editing Report.† www.animeprime.com Retrieved December    18, 2004. MacKinnon, Mark C. The Sailor Moon Role-Playing Game and Resource Book.     Ã‚  Ã‚  Ã‚  Ã‚   Guardians of   Order 1998. Mallory, Michael.   â€Å"Kid’s Anime Hits Critical Mass.† Los Angeles Times.   Oct. 2004: 18.  Ã‚   Infotrac.

Audit Proposal Essay

There are many different types of audits including internal, external, and information technology. Companies should be familiar with the types of audits that may possibly be used on an Accounting Information System (AIS). Knowing the different types of audits and where they are used will help a company be ready for an audit and make the process much smoother. There are some circumstances where auditing through a computer is not always beneficial. Auditors want to make sure they are completing their audits fully and appropriately to the best of their abilities. Types of audits used for each process Attestation, SAS 70, SAS 94, and Findings and Recommendations are four main types of Information Technology (IT) audits. If Kudler wants the auditor to provide assurance for each part of the system, an attestation audit could be used. An attestation audit can assist Kudler by issuing reports on examinations, reviews, or agreed-upon procedures. An attestation audit can provide Kudler with independent assurance on the reliability or validity of information related to the four systems under review (KPMG, 2011). A Findings and Recommendations audit can provide Kudler with other information about each system. This kind of audit includes the following: system implementations, security reviews, database application reviews, project management, IT infrastructure, and IT internal audit services. If Kudler chooses to use the Findings and Recommendations audit, this type will not produce an opinion, only a summary of the audit for each of the systems (Hunton, Bryant, & Bagranoff, 2004). An SAS 70 audit is to provide assurance about the effectiveness and existence of the company’s internal controls around a service provided to others. Kudler is not a service  provider. However, Kudler does transmit data to the Electronic Payment Clearing House for automatic submission of the credit card transactions to the applicable financial institutions. An SAS 70 could be beneficial because it is a way to prove that adequate controls are in place to protect the consumer through e-commerce. SAS 94 audits are performed with a financial statement audit and focus on the client’s AIS. It addresses the effect of IT on internal controls in a financial statement audit. Kudler will need a much broader assessment than an SAS 94. Most appropriate audit for each process There are many routes to perform an IT audit. This audit is internal and will look at both Information Technology General Controls (ITGC) and Application Controls. Specifically, the audit will focus on these categories: systems and applications, information processing facilities, management of IT and enterprise architecture, client/server, telecommunications, and intranets/extranets. The audit style will be via Findings and Recommendations as management will have to consider recommendations and the ultimate decision to make changes according to priority and budget. The audit will verify the systems and applications for efficiency and controls to ensure validity, integrity, and security of data and transactions. Kudler will need the completion of an audit on information processing facilities to assess physical conditions of the main housing units and the offsite locations to support the company’s Disaster Recovery Plan (DRP). This type of audit will evaluate the organizational structure and procedures to ensure that an efficient, controlled environment is in place. These relate to any telecommunication controls between client and server, the entire network, and any servers communicating eternally including firewalls. Auditors will assess two types of controls: security controls and access controls. Each of these types should include all three sub-controls: preventive, detective, and corrective. The AIS has an imperative need for controls to address any risks that may exist for every process and transaction. Security access controls are in place to protect data from being stolen, lost, or damaged. Access controls protect data from being released to non-authorized users, hackers, and other intruders. How the audits are conducted Kudler will conduct an information system audit by examining and evaluating  their present hardware and software. They will also examine their IT controls, systems security, risk management, and the adequacy of their current systems. They can carry out their marketing audit by evaluating the effectiveness of their marketing program and examining its capabilities. It will evaluate their functions in respect to their goals, mission, vision, and their values of Kudler, which is done externally. Kudler will examine their faculty, and their deficiencies will be identified. Another suggestion is equipment be audited, the maintenance, and an examination to determine if it’s being operated at the designed levels, safety set-up, security, and access issues. Their audit will be done by an external auditor who will examine their accounts, vouchers to support, financial information tests, evaluation of their financial statements, and also examine the internal control and make comments f or improvements. Events that prevent reliance on auditing through the computer Using computer-based accounting systems does have its disadvantages, such as certain laws pertaining to confidentiality, the requirement to protect against the loss of data through power failures, the infection of viruses, and the abundance of opportunities for hackers to steal data. Computer fraud is also a major worry; the need to initiate internal controls for all those who have access to the business’s information, particularly confidential customer information. An event that Kudler may run into with the need of stronger controls is a security breach, which entails stolen data. Kudler management can be held liable for the loss of personal customer data (University of Phoenix Virtual Organization Portal, 2013). Another event is a computer-based system with feeble controls over the data input procedures and processing, this requires the need for more thorough testing of financial transactions. The incorrect input of data can not only cause misrepresentation of financial statements in the form of incorrect asset valuations but because a mistake in data entry will give Kudler false analytical data such as sales and inventory. Lastly, an auditor will have to assume that auditing through the use of their computer-based method that their CPU and other hardware are operating properly (Bargnoff, N.A., Simkin, M.G, & Strand, C., 2008). Conclusion It is important for companies to stay positive throughout the audit process. There are many different audit processes such as Attestation, SAS70, and  SAS94 which are all effective audit strategies that may be used when auditing the company. Companies being audited should be familiar with these audit processes as well as how the audits are conducted to ensure that the process will be as smooth and stress free as possible. References Bargnoff, N.A., Simkin, M.G, & Strand, C. (2008). Core Concepts of Accounting Information Systems (10th ed.). The KPMG Survey of Corporate Responsibility Reporting 2013. 2014 KPMG International Cooperative. Retrieved July 10, 2013 from: http://www.kpmg.com/global/en/issuesandinsights/articlespublications/corporate-responsibility University of Phoenix Virtual Organization (2013). Kudler Fine Foods Intranet. Retrieved from: https://ecampus.phoenix.edu/secure/aapd/CIST/VOP/Business/Kudler2/intranet/index.asp

Personality Type Assessment

personality example Assessment (Week-2 item-by-item Assignment) CMGT/530 IT Organizational Behavior July 1, 2012 Personality emblem Assessment The first subdivision of this report details the elements that a record flake judgment typic every last(predicate)y measures. The second section contains discussion on the nature guinea pig judicial last of the author of this paper. In the tierce and last section, the author sh atomic number 18s how his personal assessment outcomes could affect his work relationships with his colleagues. Elements of Personality Type AssessmentA reputation profile assessment is typically an objective sieve where an individual gives yes or no responses to a series of organized and deeply constructed behavioral and situational questions. These objective questions at a fundagenial level assesses the individuals cognitive moral process and orientations and based on the responses classifies the individual into unmatchable of the several dispositi on flakes. Each of these reputation types is associated with different sets of realistic behaviors and melt downencies that the individuals argon most likely to exhibit.This variety of reputation types is by a personality inventory framework called the Myers-Briggs Type index (MBTI), created by Isabel Briggs Myers after extensive examination and research on the theory of psychological types introduced in the 1920s by Carl G. Jung. At the basic level, the MBTI differentiates peoples cognitive functions in foursome-spot ways, as defined by four mutually exclusive couples of the dominant or likely mental preferences, and the combinations of these four pairs go out to a set of 16 personality types (MBTItoday. rg, n. d. ). The first pair of preferences, extroversion (E) and invagination (I), is for mental energy orientation. The extroverted individuals ar expressive, assertive, outgoing, sociable, and draw their mental energy from the interactions with the international ball. The introverted individuals are reflective, reserved, quiet, and draw their mental energy from the dwelling in the informal world of thoughts and ideas (Center for Applications of psychological Type, 2012).The second pair of preferences, sensing(S) and intuition (N), is for ir sane mental cognitive process related to perception and put across of information. The individuals with dominant sensing perception cost in the present moment and are practical. They prefer simplicity, clarity, routine, and order in their free-and-easy breaks. The individuals with dominant intuition perception are inspired by creativity and innovation, and think the possibilities for future. They are drawn to the big usher and abstract theoretical concepts (Center for Applications of psychological Type, 2012).The threesome pair of preferences, thinking (T) and tactile sensation (F), is for rational mental cognitive processes of forming judgments and making decisions. The individuals who to beg in with rely on their thinking for forming judgments are objective, analytical, and logical. They use logic, reason, and cause-effect analysis to handle every problems and tasks they face for achieving results. The individuals who primarily rely on their feelings for forming judgments rely on their personal emotions and protect system.They are concerned about meeting of their actions and decisions on other people (Center for Applications of Psychological Type, 2012). The fourth pair of preferences, judging (J) and perceiving (P), is for mental orientation while dealing with right(prenominal) world. The individuals who prefer judging rely on the rational cognitive functions of thinking or feeling. They prefer the world around them to be structured, organized, and orderly. The individuals who prefer perceiving rely on the nonsensical cognitive functions of sensing and intuition.They typically are open, spontaneous, and flexible and look forward to experiencing the world in its nat ural state (Center for Applications of Psychological Type, 2012). Personality Type Self-Assessment The source use Jung typology test to complete the self assessment of his personal style and the results indicated that the source belongs to personality type ISFP that means the source prefers introversion over extroversion, sensing over intuition, feeling over thinking, and perceiving over judging (HumanMetrics, 2012).The source found himself taking the assessment test few more(prenominal) times to patronize the derived results. According to personality inventory of MBTI and the Myers and Briggs design (n. d. ), the individuals with personality type of ISFP sop up inclination to seek a peaceful, easygoing aliveness with a live and let live philosophy. They tend to enjoy life as it comes and define their own pace. They tend to be quiet, caring, considerate, and have a pleasant demeanor. They tend to be very devoted to their family and friends, and have a strong set of value t hat they cherish.They tend to dislike conflicts, disagreements, and imposing of their opinions on others (Myers and Briggs Foundation, n. d. a). After looking at the results, the generator understood some of his own tendencies and consoled himself that he did not have to good at everything. He opined that the knowledge of these personality types trick help in development a deeper reasonableness of people around him. in any case while taking the assessment, for some of the questions the source was forced to choose yes or no when he believed the answer was neither, and there were no in-between options to choose from.So the writer agrees with Robbins & test (2011) that the problem with these assessment tests is that they force a person into one type or another. According to Mccaulley (1990) every person uses all eight processes (E, I, S, N, T, F, J, and P) but intrinsically prefers one of each opposite pair. In the chemical formula course of life, people develop preferences by doing what comes most naturally. As they grow onetime(a) and wiser, they develop as well as use more of the lesser pet processes (Mccaulley, 1990).Reflecting back on his life, the writer agrees the personality type ISFP correctly indicates his default tendencies. Moreover, the writer also believes that over the years he has developed more shades to his personality and has become more balanced. Effect of Personal Assessment The assessment provided an opportunity for the writer to do some self-introspection and become more aware of self. Also the knowledge and understanding of 16 distinctive personality types helped the writer to appreciate others possessing different personality types.When employees stub understand their type preferences, they can lift their work in a way of life that best suits their style, including managing their time, problem solving, best approaches to decision making, and dealing with stress (Myers and Briggs Foundation, n. d. b) . The writer could medita te better the good and not-so-good relations he has experienced with his prior bosses and colleagues. The personality type assessment also helped the writer to go over his behavior with prior colleagues and identify the background signal for improving relationships with his colleagues at the workplace.As a bundle development manager in a leading health care organization, the writer will make use of the bare-ass understanding of his own personality to mitigate upon his managerial functions and his handling of the different situations. These functions includes managing others, developing leadership skills, organizing tasks, creating teams, training for management as well as staff, conflict resolution, motivation, coaching, diversity, credit rating as well as rewards, and tack management (Myers and Briggs Foundation, n. d. b) . References Center for Applications of Psychological Type. 2012). Mbti overview. Retrieved from http//www. capt. org/mbti-assessment/mbti-overview. htm Hu manMetrics. (2012). Jung typology test. Retrieved from http//www. humanmetrics. com/cgi-win/jtypes1. htm MBTItoday. org. (n. d. ). tale of the myers briggs type indicator. Retrieved from http//mbtitoday. org/about-the-mbti-indicator/a-mini-history-of-the-myers-briggs-type-indicator/ Mccaulley, M. H. (1990). The myers-briggs type indicator a measure for individuals.. Measurement & Evaluation In Counseling & Development (American Counseling Association), 22(4), 181.Retrieved from https//search. ebscohost. com/login. aspx? straight=true&db=f5h&AN=9705111082&site=eds-live Myers and Briggs Foundation. (n. d a). The 16 mbti types. Retrieved from http//www. myersbriggs. org/my-mbti-personality-type/mbti-basics/the-16-mbti-types. aspISFP Myers and Briggs Foundation. (n. d. b). Mbti type at work. Retrieved from http//www. myersbriggs. org/type-use-for-everyday-life/mbti-type-at-work/ Robbins, S. P. , & Judge, T. A. (2011). Organization behavior (14th ed. ). New York, NY prentice Hall.